diff --git a/BepInEx.Preloader/BepInEx.Preloader.csproj b/BepInEx.Preloader/BepInEx.Preloader.csproj
index b98ed29..b589fc1 100644
--- a/BepInEx.Preloader/BepInEx.Preloader.csproj
+++ b/BepInEx.Preloader/BepInEx.Preloader.csproj
@@ -23,8 +23,8 @@
     <DocumentationFile>..\bin\BepInEx.Preloader.xml</DocumentationFile>
   </PropertyGroup>
   <ItemGroup>
-    <Reference Include="0Harmony, Version=2.0.0.0, Culture=neutral, PublicKeyToken=null">
-      <HintPath>..\packages\HarmonyX.2.0.6\lib\net35\0Harmony.dll</HintPath>
+    <Reference Include="0Harmony, Version=2.1.0.0, Culture=neutral, PublicKeyToken=null">
+      <HintPath>..\packages\HarmonyX.2.1.0-beta.4\lib\net35\0Harmony.dll</HintPath>
       <Private>True</Private>
     </Reference>
     <Reference Include="Mono.Cecil, Version=0.10.4.0, Culture=neutral, PublicKeyToken=50cebf1cceb9d05e, processorArchitecture=MSIL">
@@ -68,9 +68,9 @@
       <Project>{4ffba620-f5ed-47f9-b90c-dad1316fd9b9}</Project>
       <Name>BepInEx</Name>
     </ProjectReference>
-    <ProjectReference Include="..\submodules\BepInEx.Harmony\BepInEx.Harmony\BepInEx.Harmony.csproj">
-      <Project>{54161cfe-ff42-4dde-b161-3a49545db5cd}</Project>
-      <Name>BepInEx.Harmony</Name>
+    <ProjectReference Include="..\submodules\BepInEx.Harmony\HarmonyXInterop\HarmonyXInterop.csproj">
+      <Project>{160f7fe0-288d-435c-9e7e-497d3e0de3a6}</Project>
+      <Name>HarmonyXInterop</Name>
     </ProjectReference>
   </ItemGroup>
   <ItemGroup>
diff --git a/BepInEx.Preloader/Entrypoint.cs b/BepInEx.Preloader/Entrypoint.cs
index 30fcbfa..1aab3ab 100644
--- a/BepInEx.Preloader/Entrypoint.cs
+++ b/BepInEx.Preloader/Entrypoint.cs
@@ -3,6 +3,7 @@ using System.IO;
 using System.Linq;
 using System.Reflection;
 using BepInEx.Preloader.RuntimeFixes;
+using HarmonyXInterop;
 
 namespace BepInEx.Preloader
 {
@@ -13,6 +14,7 @@ namespace BepInEx.Preloader
 			string bepinPath = Utility.ParentDirectory(Path.GetFullPath(EnvVars.DOORSTOP_INVOKE_DLL_PATH), 2);
 
 			Paths.SetExecutablePath(EnvVars.DOORSTOP_PROCESS_PATH, bepinPath, EnvVars.DOORSTOP_MANAGED_FOLDER_DIR);
+			HarmonyInterop.Initialize();
 			AppDomain.CurrentDomain.AssemblyResolve += LocalResolve;
 
 			PreloaderMain();
diff --git a/BepInEx.Preloader/packages.config b/BepInEx.Preloader/packages.config
index 7cbc8db..d9f0a5c 100644
--- a/BepInEx.Preloader/packages.config
+++ b/BepInEx.Preloader/packages.config
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <packages>
-  <package id="HarmonyX" version="2.0.6" targetFramework="net35" />
+  <package id="HarmonyX" version="2.1.0-beta.4" targetFramework="net35" />
   <package id="Mono.Cecil" version="0.10.4" targetFramework="net35" />
   <package id="MonoMod.RuntimeDetour" version="20.8.3.5" targetFramework="net35" />
   <package id="MonoMod.Utils" version="20.8.3.5" targetFramework="net35" />
diff --git a/BepInEx.sln b/BepInEx.sln
index fc5f004..ddef28b 100644
--- a/BepInEx.sln
+++ b/BepInEx.sln
@@ -26,6 +26,10 @@ Project("{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}") = "BepInExTests", "BepInExTest
 		{4FFBA620-F5ED-47F9-B90C-DAD1316FD9B9} = {4FFBA620-F5ED-47F9-B90C-DAD1316FD9B9}
 	EndProjectSection
 EndProject
+Project("{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}") = "HarmonyXInterop", "submodules\BepInEx.Harmony\HarmonyXInterop\HarmonyXInterop.csproj", "{160F7FE0-288D-435C-9E7E-497D3E0DE3A6}"
+EndProject
+Project("{FAE04EC0-301F-11D3-BF4B-00C04F79EFBC}") = "HarmonyX2Interop", "submodules\BepInEx.Harmony\HarmonyX2Interop\HarmonyX2Interop.csproj", "{69F6541D-A0F5-419D-B0EE-F5017F1D34F3}"
+EndProject
 Global
 	GlobalSection(SolutionConfigurationPlatforms) = preSolution
 		Debug|Any CPU = Debug|Any CPU
@@ -55,6 +59,14 @@ Global
 		{E7CD429A-D057-48E3-8C51-E5C934E8E07B}.Debug|Any CPU.ActiveCfg = Debug|x86
 		{E7CD429A-D057-48E3-8C51-E5C934E8E07B}.Debug|Any CPU.Build.0 = Debug|x86
 		{E7CD429A-D057-48E3-8C51-E5C934E8E07B}.Release|Any CPU.ActiveCfg = Release|x86
+		{160F7FE0-288D-435C-9E7E-497D3E0DE3A6}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
+		{160F7FE0-288D-435C-9E7E-497D3E0DE3A6}.Debug|Any CPU.Build.0 = Debug|Any CPU
+		{160F7FE0-288D-435C-9E7E-497D3E0DE3A6}.Release|Any CPU.ActiveCfg = Release|Any CPU
+		{160F7FE0-288D-435C-9E7E-497D3E0DE3A6}.Release|Any CPU.Build.0 = Release|Any CPU
+		{69F6541D-A0F5-419D-B0EE-F5017F1D34F3}.Debug|Any CPU.ActiveCfg = Debug|Any CPU
+		{69F6541D-A0F5-419D-B0EE-F5017F1D34F3}.Debug|Any CPU.Build.0 = Debug|Any CPU
+		{69F6541D-A0F5-419D-B0EE-F5017F1D34F3}.Release|Any CPU.ActiveCfg = Release|Any CPU
+		{69F6541D-A0F5-419D-B0EE-F5017F1D34F3}.Release|Any CPU.Build.0 = Release|Any CPU
 	EndGlobalSection
 	GlobalSection(SolutionProperties) = preSolution
 		HideSolutionNode = FALSE
@@ -63,6 +75,8 @@ Global
 		{DC89F18B-235B-4C01-AB31-AF40DCE5C4C7} = {A9071994-3533-4C1B-89DC-D817B676AB41}
 		{6E6BC1E5-5BE8-4566-B3AE-52C4CB218AEB} = {A9071994-3533-4C1B-89DC-D817B676AB41}
 		{54161CFE-FF42-4DDE-B161-3A49545DB5CD} = {BAC58F7E-AAD8-4D0C-9490-9765ACBBA6FB}
+		{160F7FE0-288D-435C-9E7E-497D3E0DE3A6} = {BAC58F7E-AAD8-4D0C-9490-9765ACBBA6FB}
+		{69F6541D-A0F5-419D-B0EE-F5017F1D34F3} = {BAC58F7E-AAD8-4D0C-9490-9765ACBBA6FB}
 	EndGlobalSection
 	GlobalSection(ExtensibilityGlobals) = postSolution
 		SolutionGuid = {55AC11EF-F568-4C79-A356-7ED9510145B1}
diff --git a/BepInEx/BepInEx.csproj b/BepInEx/BepInEx.csproj
index 54a7296..af4f1d5 100644
--- a/BepInEx/BepInEx.csproj
+++ b/BepInEx/BepInEx.csproj
@@ -41,8 +41,8 @@
     <AllowUnsafeBlocks>true</AllowUnsafeBlocks>
   </PropertyGroup>
   <ItemGroup>
-    <Reference Include="0Harmony, Version=2.0.0.0, Culture=neutral, PublicKeyToken=null">
-      <HintPath>..\packages\HarmonyX.2.0.6\lib\net35\0Harmony.dll</HintPath>
+    <Reference Include="0Harmony, Version=2.1.0.0, Culture=neutral, PublicKeyToken=null">
+      <HintPath>..\packages\HarmonyX.2.1.0-beta.4\lib\net35\0Harmony.dll</HintPath>
       <Private>True</Private>
     </Reference>
     <Reference Include="Mono.Cecil, Version=0.10.4.0, Culture=neutral, PublicKeyToken=50cebf1cceb9d05e, processorArchitecture=MSIL">
diff --git a/BepInEx/packages.config b/BepInEx/packages.config
index 7cbc8db..d9f0a5c 100644
--- a/BepInEx/packages.config
+++ b/BepInEx/packages.config
@@ -1,6 +1,6 @@
 <?xml version="1.0" encoding="utf-8"?>
 <packages>
-  <package id="HarmonyX" version="2.0.6" targetFramework="net35" />
+  <package id="HarmonyX" version="2.1.0-beta.4" targetFramework="net35" />
   <package id="Mono.Cecil" version="0.10.4" targetFramework="net35" />
   <package id="MonoMod.RuntimeDetour" version="20.8.3.5" targetFramework="net35" />
   <package id="MonoMod.Utils" version="20.8.3.5" targetFramework="net35" />